They will be trying to emphasize the play of their forwards and centers. If you want to stop their offense, you might select your centers and forwards based more on their defensive, rebounding, and shot blocking skills, and less on their offensive skills. You could also use a 2-3 zone yourself.
On offense, you will be able to get more outside shots. So you might use an offense that gives you more outside shooting. If your guards aren't very good shots or lack range, this might not be such a good idea.
And you also need to look at the other team's sector ratings. They might be using a 2-3 zone because their forwards and center aren't good defenders and their guards are great defenders. So they use an extra player in back to make up for their weakness.