Use M2M. I've always used M2M against Push the Ball or Base Offense or such neutral offenses. Its the safest option by far. But a little research can do wonders. I mean, if he has a player who is clearly superior to his other players and that player is a guard, you may consider playing the 3-2, because it is likely that his best player will hog the ball. You could also play M2M and set your best defender to defend as SG or PG(the position he plays). Technically M2M defenses are considered to be the best against neutral offenses, don't know how much of that is true.
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