If the score leads significantly, using Follow Depth Chart, the starters' playing time is about 28 minutes, give or take a few minutes.
This game
(129647754) is an example, the starters of my PF and C positions play 28 minutes and backups play 20 minutes.
If the score is very close or even slightly behind the opponent, then Follow Depth Chart is indeed not effective.
However, if the backup players are significantly stronger than the starters, using Coach Picks from Depth Chart might work.
For example, in this (old) game
(37151492), my PG starter plays 29 minutes, and the backup plays 19 minutes.
If there is no restriction on a single position playing for 28 minutes, and the backups are close in strength to the starters, it is possible to achieve this by using Coach Picks from Depth Chart or Let Coach Decide.
In this B3 game
(129757425), TWT's Z. Bevalds plays 25 minutes, and according to BBAPI, he plays 8 minutes at PG, 8 minutes at SG, and 10 minutes at SF.
I guess TWT probably set Z. Bevalds as the backup for the PG, SG, and SF positions.