we have no info on your players' skills...
tell us what you think what your players are good at... inside game? perimeter? outside shooters?
also, do they have good stamina? all at least inept level? if no, exactly how many?
if they are weak in rebounds, they have to be good in others... let's say, outside defense?
if so, run a 3-2 offense and pray that your opponent doesn't play inside game...
(look inside, low post are examples of inside games)
if you don't believe me, read more about tactics under the rules page...
http://www.buzzerbeater.com/BBWeb/rules.aspx?nav=Tactics