I'm about halfway through my first game with one position set, and the rest blank. So far it's working out better than expected. My highest salary players were made to be my other starters, but the substitutions are pretty interesting to watch. The minutes are fairly balanced, and players are in every position. My normal C has played from PG to PF already.
I'll have to review after the game is done, but this could be my new training method. If minute distribution is becoming an issue, I'll just use it on short weeks only.