I sold my soul into the LI thing a while ago. But I keep my interest alive by dreaming (often) of the perfect Princeton team.
So... (just to keep the Princeton aspect of this thread alive) in real life descriptions of the offense, it's everyone's ability to drive, shoot the three, and pass that make the offense work. And you want those attributes on every player. So I say: Skimp on IS. Get players with great guard skills in the 1-2-3. At the 4 slot, play a guy who's basically a guard with ID/RB. And at 5, play a big who's a stellar rebounder/defender, can dish well and can shoot passably. Then adjust your lineup to try and get your best 1-3 guy matched up with their worst 1-3 defender.
Bonus: if you also run a 3-2 your 1-3 slots are virtually interchangeable and can be filled with the abundance of combo guards readily available on the TL. Then all you have to do is train 2 weird bigs.