The only way you are able to do this is by manually setting your players as starter, backup and reserve so they won't get subbed out when up 25, or if you want them out when down by 40, just play them as a starter. Another thing I have observed while using Strictly Follow Depth Chart is that when you are in a blowout, both teams' starters will sit on the bench. Another thing is, if you play Strictly Follow Depth Chart Until 4th, you are basically letting the coach use his own judgement to try to win the game in the 4th quarter.