Base Offense can work, but you need to have players with good secondaries at every position. Here is what I think about it.
Pros
-Difficult to stop
-Offense isn't limited
-Players might sell for a nice profit
-Bigs who can shoot jumpers, guards can post up
-Few to no offensive weaknesses
-Able to play other tactics
Cons
-Can be expensive to players for BO
-It may take a while to get the right players
-Opposing OD might be able to shut it down, if it is flawed
It would be nice if someone were to pioneer this big time and try it.