The main risk will be that he either fouls out or that your coach randomly subs him out for a few minutes (which can happen). Shouldn't affect your ability to win games seeing u win by a lot anyway.
It can not happen when you select "Strictly follow depth chart", "Let them play" and set the player as starter, backup and reserve on a single position.
Only if the player gets injured or fouled out, he won't play 48 minutes.
When I run into an invisible spider web, I instantly become a kung-fu master.