Strictly follow depth chart - Starters starts and keep playing until they are in foul trouble (depends on your settings) or are tired enough that their become not as effective (it matters a bit how good the back up is, most probably). You can expect 24+ minutes (with poor stamina) or rather 30+ minutes for starters baring
a) blow outs - it influence lineup in 4th quarter if you are up by 20+ points; usually it tries to play your reserves and tends to try to get your dress but not assigned (to any of 15 slots of lineup) some minutes. It would be long pargraph about it because it can be complicating assuming how different patterns of lineups can be used. However I have one question - did someone try to use Player A - Player B (backup) - Player A (reserve) in blowouts often? (with strictly follow d.c.) Did player A play majority of 4th quarter?
b)you can fill the whole spot with one player, just enter his name multiple times (as starter, backup and reserve). He has a better chance to play 40+ minutes then (baring injuries, foul troubles,...)
This option is best to handle your players' minutes.
Coach picks from depth chart - From the three slots of lineup for each position coach tries to play the best one and backs up him with the second best one (actual tireness probabla already counted) - if any available. The starter should start but can be subbed immediately (not experinced that he would nto start at all but maybe it is possible) resulting in no (less than 1 minute) PT. Coach can let starter play iof he thinks it is a good(best?) option but can prefer reserve over backups and etc. Simply he creates his own hierarchy for the posiion and the match (how it turns out is inluenced by fouls tireness, injuries). In blow outs it is probable that he would play the last one in his hierarchy (but I have no experience with this). I guess coach would use a player outside of the assigned trio if he thinks he is shot of better options (=he thinks other player is better at the time) however it should not happen at first half at all. I guess 4th quarter, OtTs, blowouts and last minutes of quarters (defence, FT, 3PT) are cases when this can happen.