To do that you would have to have players with high OD, RB, and ST. Most players with high OD aren't being trained in RB, and vice-versa. Theoretically, yes. You could do that. But the builds would be so out of the ordinary. Also, if the other team has at least 2 amazing bigs with RB even close to yours then you won't really lower the difference.
I have 1757 players for sale and I'm $25,835,360 in debt. Buy them at outrageous prices, or be selfish and make me go bankrupt. You decide, BB.