I've had this happen to me once with my previous franchise. I had 3 of 5 starters get injured in the first game of the championship series. Two had permanent injuries and one was in-game and returned for the following game. But it was awful and I ended up losing the series. Worse yet I was "shooting the moon" with the economy and had built my team for promotion and needed not only the promotion bump but also the better financials from being in a higher league. I had to blow everything up and it took me several seasons to recover back. I was pretty upset (mostly at myself).